Positive BRAF Variant Expression is Associated With Improved Melanoma Prognosis
Source: Dermatology Advisor, March 2023
Positive BRAF V600E expression is significantly associated with nonrecurrent disease and better survival in patients with superficial spreading melanomas (SSMs), according to study results published in Dermatology.
Researchers conducted a retrospective review of melanoma cases recorded in the Danish Pathology Register between 1995 and 2015. Clinical and histopathological data were retrieved for each case. Melanoma-specific and disease-free survival rates were calculated using data from medical records, which were followed until death or October 1, 2020. Intratumor heterogeneity was also assessed using a combination of immunohistochemistry and mRNA analysis.
Samples from 166 (mean age, 57.7 years: 51.8% men) participants with SSMs were included in the study. The most common tumor site was the trunk (50.0%) or leg (24.7%). The majority of participants had localized disease, although 22.9% had at least 1 lymph node metastasis.