Phase 1 Trial of Darovasertib Monotherapy Enrolls First Patient With Uveal Melanoma
Source: Targeted Oncology, September 2022
A patient enrolled in the phase 1 NADOM trial of darovasertib alone in non-metastatic uveal melanoma shows early signs of clinical efficacy.
The first patient has been enrolled in the phase 1 NADOM clinical trial (NCT05187884) evaluating darovasertib (IDE196) as a monotherapy in patients with both neoadjuvant and adjuvant, primary, non-metastatic uveal melanoma, according to IDEAYA Biosciences, Inc.
“We are excited to be leading this ground-breaking clinical study treating patients with darovasertib in the neoadjuvant and adjuvant settings. The concept for this study originated from anecdotal observations in a metastatic uveal melanoma patient treated with darovasertib who also had an intact primary lesion in the eye, where a reduction in the eye lesion was observed at an initial scan with improvement in visual symptoms," said Anthony Joshua, MBBS, PhD, FRACP, professor, head of the Department of Medical Oncology, Kinghorn Cancer Center, St. Vincent’s Hospital Sydney, in a press release.