Nivolumab Plus Relatlimab Induces Durable Responses in Advanced Melanoma
Source: Onc Live, March 2023
The combination of nivolumab (nivolumab) and relatlimab (Opdualag) demonstrated clinical benefit with a manageable safety profile in patients with advanced melanoma who have progressed on prior PD-L1 or PD-1 inhibitors, regardless of PD-L1 and LAG-3 expression, according to findings from the ongoing phase 1/2a RELATIVITY-020 trial (NCT01968109).
At a clinical cutoff date of January 4, 2021, and a minimum follow-up of 19.4 months, among evaluable patients, the overall response rate (ORR) by blinded independent central review (BICR) was 12.0% (95% CI, 8.8%-15.8%) in patients who had progressed on 1 prior PD-1 inhibitor (D1; n = 351) and 9.2% (95% CI, 5.2%-14.7%) in those who had progressed on at least 1 prior PD-1/PD-L1 inhibitor (D2; n = 163).
“Among patients with advanced melanoma who had progressed following anti–PD-1-based therapy, nivolumab plus relatlimab triggered durable tumor regressions and had a manageable safety profile,” Evan J. Lipson, MD, of Sidney Kimmel Comprehensive Cancer Center in Baltimore, Maryland, said to OncLive®.