Neurofibromatosis Type 1 Linked to Greater Skin Cancer Risk
Source: AJMC, October 2022
The risks of 4 types of skin cancers were investigated among patients who have neurofibromatosis type 1, a multisystem autosomal dominant genetic syndrome characterized by loss of neurofibromin.
Basal cell carcinoma (BCC), squamous cell carcinoma (SCC), keratinocyte carcinoma, and melanoma risks were found to be higher among a group of 4122 patients who had neurofibromatosis type 1 (NF1), according to new study findings in JAMA Dermatology.
Patients who have NF1 do not have neurofibromin, a tumor suppressor gene, and because of this, they can develop benign skin, eye, and nervous system tumors and have a higher risk of nervous system or other solid organ cancers, the study investigators wrote.