Mitochondrial Fragmentation Plays Key Role in Spreading of Melanoma Cancer Cells

Source: Pharmacy Times, June 2023

Investigators from the Barts Cancer Institute at Queen Mary University of London have discovered that mitochondrial dynamics control migration of melanoma skin cancer cells, according to the results of a study published in Nature Communications.

They also discovered that AMP-activated protein kinase (AMPK) is an essential sensor for tumor dissemination.

“These metastatic cells are rewiring themselves to be very efficient,” Eva Crosas-Molist from the Queen Mary University of London, said in a statement. “They only need low levels of energy to move, which helps them to survive in the potentially stressful environments they are migrating to, where there may be a lack of nutrients or oxygen.”