Metastatic Melanoma: Key Trial Updates

Source: OncLive, September 2019

Sanjiv S. Agarwala, MD: Dirk, talking about the BRAF-positive population, the COLUMBUS trial was updated, you know, with the most recent BRAF/MEK combo. And Alex’s points are very interesting. That data were looking more impressive. Were you impressed with that? Is there something in that combination that’s different? What are your thoughts on that update?

Dirk Schadendorf, MD, PhD: I think the clinical efficacy data for encorafenib and binimetinib are very well in line with the other BRAF/MEK combinations. Third in market, I think there is absolutely no doubt that this combination is working. It’s clinically efficient and is working as good as what we have in hand.

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