Melanoma Patients Treated With Dabrafenib, Trametinib Have Overall Survival Rates of More Than 2 Years
Source: Cancer Therapy Advisor, February 2016
Patients with BRAF V600E-mutant metastatic melanoma who were treated with a combination of the mitogen-activated protein kinase (MAPK) inhibitors dabrafenib and trametinib demonstrated significant improvement in overall and progression-free survival.1
In this study, investigators sought to report the overall survival (OS) and clinical characteristics of BRAF inhibitor-naïve patients with BRAF V600 mutation-positive metastatic melanoma treated with dabrafenib plus trametinib. There were 2 cohorts: non-randomly assigned patients (part B; 24 patients) and randomly assigned patients (part C; 54 patients). Both cohorts received dabrafenib 150 mg twice daily plus trametinib 2 mg daily.
“This study is the longest-term data we have for combined targeted therapy,” said lead study author Georgina Long, MD, PhD, of the University of Sydney and Melanoma Institute Australia, Sydney, in an interview with Cancer Therapy Advisor.
Results showed that median OS was 27.4 months for those in part B and 25.0 months for patients in part C. At 1, 2, and 3 years, OS was 72%, 60%, and 47%, respectively, and 80%, 51%, and 38%, respectively.