Mediterranean Diet and Immune Checkpoint Blockade Outcomes in Advanced Melanoma
Source: The Asco Post, February 2023
In the PRIMM study reported in JAMA Oncology, Bolte et al found that consumption of a Mediterranean diet was associated with a high probability of objective response and 12-month progression-free survival among patients receiving immune checkpoint blockade treatment for advanced melanoma.
As stated by the investigators, “Nutrition, through its association with the immune system and gut microbiome, is a poorly explored but appealing target with potential to improve the efficacy and tolerability of immune checkpoint blockade.”
Study Details
The multicenter trial included 91 immune checkpoint blockade–naive patients from the UK (n = 47) and the Netherlands (n = 44) who received immune checkpoint blockade between 2018 and 2021. Treatment consisted of a PD-1 inhibitor, a CTLA-4 inhibitor, or both.