Low-Dose IL-2 Shows Promise in Colitis

Source: Medpage Today, January 2021

Low doses of the recombinant T-cell growth factor interleukin 2 (IL-2, aldesleukin, Proleukin) were well tolerated among patients with moderate-to-severe ulcerative colitis in a small 8-week study, with only one patient being withdrawn because of a dose-limiting toxicity, a researcher reported.

There also were preliminary suggestions of efficacy, with 38.4% of the 26 patients enrolled achieving a clinical response and 15.4% being in clinical remission by week 8, according to Jessica R. Allegretti, MD, of Harvard University in Boston.

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