INVESTIGATING GENOMIC CHARACTERISTICS OF ACRAL, MUCOSAL, AND VULVOVAGINAL MELANOMAS
Source: Physicians Weekly, May 2023
The following is a summary of “Distinct genomic features in a retrospective cohort of mucosal, acral, and vulvovaginal melanomas,” published in the MAY 2023 issue of Dermatology by Shi, et al.
Sun-protected melanomas have a different pathogenesis than sun-exposed melanomas. While sun-protected melanomas share several epidemiologic factors, their genetic heterogeneity is not well understood. For a study, researchers sought to investigate the genomic profile of melanomas in sun-protected areas (acral, mucosal, and vulvovaginal) and to determine whether mucosal melanomas have distinct genomic features.
Whole transcriptome messenger RNA and DNA sequencing (1,711 genes), messenger RNA expression profiling, tumor mutational burden, ultraviolet signature, and copy number variant analysis were performed on 29 volar/digital acral, 7 mucosal, and 6 vulvovaginal melanomas.