Immune checkpoint inhibitor therapy may increase the incidence of treatment-related necrosis after stereotactic radiosurgery for brain metastases: a systematic review and meta-analysis

Source: docwirenews, November 2020

OBJECTIVES: To compare the incidence of treatment-related necrosis between combination SRS+ICI therapy and SRS therapy alone in patients with brain metastases from melanoma and non-small cell lung cancer (NSCLC).

METHODS: A systematic literature search of Ovid-MEDLINE and EMBASE was performed up to August 10, 2020.

The difference in the pooled incidence of treatment-related necrosis after SRS+ICI or SRS alone was evaluated.

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