Histologic margin status can help predict lentigo maligna melanoma recurrence

Source: Healio, August 2023

Key takeaways:

  • Histologic margin status is a predictor of lentigo maligna melanoma progression.
  • In a univariate analysis, age of 71 years and older was correlated with worse overall survival and progression-free survival.

The strongest predictor of lentigo maligna melanoma progression is histologic margin status, and patients with margins less than 3 mm should consider re-excision, according to a study.

“Lentigo maligna (LM, in situ) and lentigo maligna melanoma (LMM, invasive) is a subtype of melanoma occurring on sun-damaged skin and with increased incidence with age,” Mai P. Hoang, MD, of Massachusetts General Hospital and Harvard Medical School, and colleagues wrote. “LM/LMM poses a treatment challenge due to multiple factors, including frequent head and neck location, large clinical size and propensity for recurrence.”