Encorafenib/Binimetinib Combo Continues to Show Survival Benefits in BRAF V600-Mutant Melanoma

Source: OncLive, May 2020

The combination of encorafenib (Braftovi) and binimetinib (Mektovi) demonstrated continuing benefit in overall survival (OS) and progression-free survival (PFS) for patients with BRAF V600—mutant melanoma, according to an updated analysis of the COLUMBUS (NCT01909453) trial during a poster presentation at the 2020 American Society of Clinical Oncology Virtual Scientific Program.1

The 2-part, phase 3 trial compared the combination of encorafenib and binimetinib versus encorafenib or vemurafenib (Zelboraf) in 577 patients enrolled across 28 countries and from 162 hospitals between December 2013 and November 2015.

In part 1, patients with unresectable or locally advanced or metastatic melanoma who were treatment naïve or progressed after prior first-line immunotherapy with a BRAF V600 mutation were equally randomized into 3 arms: encorafenib (450 mg once daily) and binimetinib (45 mg twice a day); vemurafenib (960 mg twice a day); or encorafenib (300 mg once daily).2