Dr. Weber Discusses Unmet Needs in Ocular and Mucosal Melanoma

Source: OncLive, December 2021

Jeffrey S. Weber, MD, PhD, discusses unmet needs in ocular and mucosal melanoma.

Jeffrey S. Weber, MD, PhD, Laura and Isaac Perlmutter Professor of Oncology, Department of Medicine, NYU Grossman School of Medicine, deputy director, Perlmutter Cancer Center, codirector, Melanoma Research Program, NYU Langone Health, discusses unmet needs in ocular and mucosal melanoma.

Despite significant advances in the treatment of patients with melanoma, such as the integration of nivolumab (Opdivo) plus ipilimumab (Yervoy), around half of patients treated need additional therapy, Weber says. As such, therapeutic development is important in melanoma, particularly for the ocular and mucosal subtypes.

In August 2021, the FDA granted a priority review designation to the biologics license application of tebentafusp (IMCgp100) for the treatment of adult patients with HLA-A*02:01–positive metastatic uveal melanoma. Data from the phase 3 IMCgp100-202 trial (NCT03070392) demonstrated a median overall survival of 21.7 months with tebentafusp vs 16 months with investigator’s choice of pembrolizumab (Keytruda), ipilimumab (Yervoy), or dacarbazine in this patient population.

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