Dr. Luke on the Importance of BRAF in Melanoma

Source: OncLive, October 2020

Jason J. Luke, MD, FACP, an associate professor of medicine in the Division of Hematology/Oncology and director of the Cancer Immunotherapeutics Center Immunology and Immunotherapy Program at the University of Pittsburgh Medical Center Hillman Cancer Center, discusses the importance of BRAF in melanoma.

BRAF, found in half of all patients with melanoma, is a foundational mutation that was 1 of the seminal targets for early targeted agents, says Luke.

BRAF mutations also have to occur in conjunction with other mutations or dysregulations of the tumor.

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