Dr Hamid on the Rationale For Investigating Fianlimab Plus Cemiplimab in Melanoma

Source: OncLive, November 2023

Omid Hamid, MD, director, Melanoma Program, The Angeles Clinic and Research Institute, Cedars-Sinai, discusses the rationale for a phase 1 trial of fianlimab plus cemiplimab in patients with advanced melanoma who have received prior adjuvant PD-1 inhibitors.
Omid Hamid, MD, director, Melanoma Program, The Angeles Clinic and Research Institute, Cedars-Sinai, discusses the rationale for a phase 1 trial of fianlimab (formerly REGN 3767) plus cemiplimab-rwlc (Libtayo) in patients with advanced melanoma who have received prior adjuvant PD-1 inhibitors.

Fianlimab is a LAG3 inhibitor, and cemiplimab is a PD-1 inhibitor. The combination of PD-1 inhibition and LAG3 inhibition has been shown to improve response rates and progression-free survival in patients with advanced melanoma, Hamid says. Initial data from this phase 1 trial were presented at the 2022 ESMO Congress. These data demonstrated a 64% overall response rate (ORR) in patients with advanced melanoma who were naive to PD-1 inhibition.

Updated findings from this trial, which were presented at the 2023 ASCO Annual Meeting, include follow-up data from the PD-1 inhibitor–naive population. The presentation also included novel data in a population of patients with pretreated melanoma, including those with prior exposure to adjuvant PD-1 inhibitors.
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