Dermoscopic Features in Melanoma Associated With 3 Genes
Source: Dermatology Times, April 2023
There are 3-gene expression profiling pigmented lesion assays (3-GEP PLA) which detect the 3 genes in a noninvasive manner. These genes are Long Intergenic Non-Protein Coding RNA 518 (LINC00518), Preferentially Expressed Antigen in Melanoma (PRAME), and mutated Telomerase Reverse Transcriptase (TERT).
In a recent retrospective case-control study,1 researchers sought to identify dermoscopic features unique associated with the 3 genes, citing an absence of literature related to melanoma-associated genes and dermoscopic features.
Between April 2021 and August 2021, researchers collected and analyzed data from 351 unique patients, amassing a total of 510 suspicious pigmented skin lesions. All patients had undergone 3-GEP PLA testing and adhesive patch sample collection. However, 67 samples were deemed insufficient for testing, and 50 cases did not have dermoscopy or clinical images associated with their medical record. These were excluded from analysis, leaving 393 clinical samples remaining.