Common moles could serve as players in battling melanoma and preventing its recurrence

Source: Massachusetts General Hospital, June 2021

Researchers at Massachusetts General Hospital (MGH) have found that a subset of white blood cells known as CD4+ T cells reside naturally in moles on the body and could be activated as part of a novel strategy to treat melanoma and generate a potent immunity against its recurrence. The team learned that common moles are immunogenic targets for killer CD4+ T cells which, through their activation, could potentially broaden the body’s antitumor response and overcome the obstacles to current cancer immunotherapies, such as checkpoint inhibitors.

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