Biological Patterns in Pediatric Melanoma

Source: Dermatology Times, May 2023

In a recent systematic review, researchers sought to evaluate the historical evidence of pediatric melanoma, citing the current evidence’s heterogeneity, particularly regarding melanoma subtypes and prognosis. Furthermore, they intended to highlight major sources of pediatric melanoma heterogeneity, particularly among single patients.

According to study authors, childhood cutaneous melanoma has a global incidence of 2 to 5 cases per million people annually, accounting for just 1% of pediatric malignancies.

Using PubMed, Embase, and Cochrane Central databases, researchers conducted both a systematic review and an individual patient meta-analysis including data from 1948 through January 2021. Included search terms were melanoma and child, or childhood, children, infan, pediatr, or puber.