AP-2alpha-mediated activation of E2F and EZH2 drives melanoma metastasis
Source: MDLinx, July 2021
To clarify the role of the AP-2alpha transcription factor, which is encoded by TFAP2A, in melanoma metastasis, researchers undertook this study. They found that via transcriptional activation of genes within the E2F pathway, including EZH2, AP-2alpha facilitated melanoma metastasis.
