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Scientific Journals for April 2015

Id1 suppresses anti-tumour immune responses and promotes tumour progression by impairing myeloid cell maturation.

Marianna Papaspyridonos, Irina Matei, Yujie Huang, Maria do Rosario Andre, Helene Brazier-Mitouart, Janelle C. Waite, April S. Chan, Julie Kalter, Ilyssa Ramos, Qi Wu, Caitlin Williams, Jedd D. Wolchok, Paul B. Chapman, Hector Peinado, Niroshana Anandasabapathy, Allyson J. Ocean, Rosandra N. Kaplan, Jeffrey P. Greenfield, Jacqueline Bromberg, Dimitris Skokos, David Lyden.

Nature Communications, 2015; 6: 6840
DOI:1038/ncomms7840

PNAS

Multifunctional bioscaffolds for 3D culture of melanoma cells reveal increased MMP activity and migration with BRAF kinase inhibition

Jennifer L. Leighta, Emi Y. Tokudaa, Caitlin E. Jonesa, Austin J. Lina and Kristi S. Ansetha,

5366–5371 | PNAS | April 28, 2015 | vol. 112 | no. 17 www.pnas.org/cgi/
doi/10.1073/pnas.1505662112

Nature

Cell Death and Differentiation advance

Pharmacological targeting of guanosine monophosphate synthase suppresses melanoma cell invasion and tumorigenicity

A Bianchi-Smiraglia1, J A Wawrzyniak1, A Bagati1, E K Marvin1, J Ackroyd2, S Moparthy1, W Bshara3, E E Fink1, C E Foley1, G E Morozevich4, A E Berman4, D S Shewach2 and M A Nikiforov1

  1. 1Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
  2. 2Department of Pharmacology, University of Michigan, Ann Arbor, MI 48109, USA
  3. 3Department of Pathology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
  4. 4Orekhovich Institute of Biomedical Chemistry, Moscow 119121, Russia

online publication 24 April 2015;
doi: 10.1038/cdd.2015.47

The New England Journal of Medicine

CORRESPONDENCE

Rapid Eradication of a Bulky Melanoma Mass with One Dose of Immunotherapy

Paul B. Chapman, M.D.
Sandra P. D’Angelo, M.D.
Jedd D. Wolchok, M.D., Ph.D.
Memorial Sloan Kettering Cancer Center, New York, NY
chapmanp@mskcc.org

Supported by Bristol-Myers Squibb.

Disclosure forms provided by the authors are available with the full text of this letter at NEJM.org.

This letter was published on April 20, 2015, at NEJM.org.

 April 20, 2015
DOI: 10.1056/NEJMc1501894

The New England Journal of Medicine

Pembrolizumab versus Ipilimumab in Advanced Melanoma

Caroline Robert, M.D., Ph.D., Jacob Schachter, M.D., Georgina V. Long, M.D., Ph.D., Ana Arance, M.D., Ph.D., Jean Jacques Grob, M.D., Ph.D., Laurent Mortier, M.D., Ph.D., Adil Daud, M.D., Matteo S. Carlino, M.B., B.S., Catriona McNeil, M.D., Ph.D., Michal Lotem, M.D., James Larkin, M.D., Ph.D., Paul Lorigan, M.D., Bart Neyns, M.D., Ph.D., Christian U. Blank, M.D., Ph.D., Omid Hamid, M.D., Christine Mateus, M.D., Ronnie Shapira-Frommer, M.D., Michele Kosh, R.N., B.S.N., Honghong Zhou, Ph.D., Nageatte Ibrahim, M.D., Scot Ebbinghaus, M.D., and Antoni Ribas, M.D., Ph.D. for the KEYNOTE-006 investigators

April 19, 2015
DOI: 10.1056/NEJMoa1503093

NATURE REVIEWS GENETICS | RESEARCH HIGHLIGHT

CLINICAL GENETICS

Sequencing for tailored melanoma immunotherapy

Nature Reviews Genetics16,259(2015)

Published online 17 April 2015
doi:10.1038/nrg3945

Multifunctional bioscaffolds for 3D culture of melanoma cells reveal increased MMP activity and migration with BRAF kinase inhibition

  1. Published online before printApril 13, 2015,
    doi:10.1073/pnas.1505662112
    PNASApril 13, 2015

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Laboratory Investigation , (13 April 2015) |

Phenotypic diversity of patient-derived melanoma populations in stem cell medium

Malgorzata Sztiller-Sikorska, Mariusz L Hartman, Beata Talar, Justyna Jakubowska, Izabela Zalesna and Malgorzata Czyz

doi:10.1038/labinvest.2015.48

Vaccination

Researchers create personalised vaccines for patients with advanced melanoma

The Pharmaceutical Journal, 10 APR 2015By Janna Lawrence

The Pharmaceutical Journal, 25 April 2015, Vol 294, No 7859, online |
URI: 20068310

Apoptosis Induced by Ginkgo biloba (EGb761) in Melanoma Cells Is Mcl-1-Dependent

  • Yufang Wang, Junping Lv ,Yao Cheng, Jipei Du, Degao Chen, Chengtao Li, Ji Zhang
  • Published: April 10, 2015
  • DOI: 10.1371/journal.pone.0124812

Surgery for melanoma is often delayed in Medicare patients, study finds

  1. Michael McCarthy

BMJ 2015; 350 
doi: http://dx.doi.org/10.1136/bmj.h1886 
(Published 09 April 2015)Cite this as: BMJ 2015;350:h1886

____________________________________________________________________________________________________________

Gene electrotransfer of plasmid AMEP, an integrin-targeted therapy, has antitumor and antiangiogenic action in murine B16 melanoma

M Bosnjak, T Dolinsek, M Cemazar, S Kranjc, T Blagus, B Markelc, M Stimac, J Zavrsnik, U Kamensek, L Heller, C Bouquet, B Turk and G Sersa

Gene Therapy , (9 April 2015)
doi:10.1038/gt.2015.26

Thomas NE, Edmiston SN, Alexander A, et al. Association Between NRAS and BRAF Mutational Status and Melanoma-Specific Survival Among Patients With Higher-Risk Primary Melanoma. JAMA Oncol. Published online April 09, 2015. doi:10.1001/jamaoncol.2015.0493.

IMMUNOTHERAPY

CheckMate—has nivolumab beaten melanoma?

Nature Reviews Clinical Oncology (2015)

doi:10.1038/nrclinonc.2015.67

Published online 07 April 2015

Expression of the class 1 histone deacetylases HDAC8 and 3 are associated with improved survival of patients with metastatic melanoma

James S Wilmott, Andrew J Colebatch, Hojabr Kakavand, Ping Shang,Matteo S Carlino, John F Thompson, Georgina V Long, Richard A Scolyer and Peter Hersey

Modern Pathology , (3 April 2015) |
doi:10.1038/modpathol.2015.34

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