Undersleeping is a Potential Risk Factor for Cutaneous Melanoma
Source: Dermatology Times, March 2025
Two-sample Mendelian randomization analysis explored lifestyle factors such as sleep, smoking, alcohol consumption, and sedentary behavior.
Researchers explored the genetic relationship between poor lifestyle habits and the risk of developing cutaneous melanoma.1 Two-sample Mendelian randomization analysis showed that undersleeping is causally associated with the risk of melanoma. The connection between sleep and cutaneous melanoma has not been studied prior to this literature.
Investigators applied Mendelian randomization by using the genome?wide association studies (GWAS) statistics of poor lifestyle habits and cutaneous melanoma. These habits were identified as undersleeping, smoking, alcohol consumption, and sedentary behavior. The GWAS data was downloaded from the IEU OpenGWAS project and GWAS Catalog. The study was approved by the Ethics Committee of Shengli Oilfield Central Hospital.