Smart nanotherapy enhances immune attack on melanoma
Source: PHYS.ORG, April 2025
Researchers have developed an innovative nano-immune agonist that significantly improves immunotherapy outcomes for melanoma—a highly aggressive and hard-to-treat form of skin cancer.
The study, published in the Journal of Colloid and Interface Science, introduces a biodegradable therapeutic nanomaterial called pLCGM-OVA. The team included Prof. Wu Zhengyan from the Hefei Institutes of Physical Science of the Chinese Academy of Sciences, in collaboration with Prof. Zhang Guilong from Binzhou Medical University.
Melanoma remains a clinical challenge largely due to its strong immunosuppressive tumor microenvironment, which weakens the effectiveness of conventional immune checkpoint inhibitors. To overcome this hurdle, the researchers designed a multifunctional nanoplatform capable of reshaping the tumor microenvironment and enhancing the body’s natural immune defense against cancer.