Novel ‘Gut-on-a-Chip’ Model Uncovers Biomarker for Immunotherapy in Melanoma
Source: Doc Wire News, February 2025
A team of researchers from the European Institute of Oncology and the Politecnico di Milano developed the novel “gut-on-a-chip”: a miniature model of the human intestine on a chip-sized device capable of reproducing the main features of intestinal inflammation as a biomarker for response to immune checkpoint inhibitors in patients with melanoma.
The results were published in Nature Biomedical Engineering.
The research group developed a model that was suitable for real-time multiomic detections, which consists of a vascular channel seeded with human microvascular endothelial cells and an intestinal channel with intestinal organoids derived from human induced pluripotent stem cells separated by an extracellular matrix–like gel layer.