Does Indoor Tanning Affect Melanoma Tumor Mutational Burden?
Source: Medscape, December 2024
TOPLINE:
Indoor tanning exposure was not associated with tumor mutational burden (TMB) in patients with cutaneous melanoma, in a retrospective cohort study. Higher TMB was linked to older age, head and neck tumors, and a history of nonmelanoma skin cancer (NMSC).
METHODOLOGY:
- Researchers conducted a retrospective cohort study at a tertiary care cancer center between 2013 and 2022.
- A total of 617 patients (median age at diagnosis, 61 years; 62.9% men) with melanoma who had next-generation sequencing data and indoor tanning bed exposure history available were included.
- Analysis involved multivariable modeling to evaluate the association between tanning bed use and TMB.
- Patients’ demographics, pathologic staging, TMB, and dermatologic history, including Fitzpatrick skin type, history of exposure to ultraviolet (UV) light, indoor tanning, NMSC, atypical nevi, and blistering sunburns, were considered for the analysis.