Using Polygenic Risk Scores to Stratify Patients Based on Risk of Invasive Cutaneous Melanoma

Source: Doc Wire News, August 2024

Polygenic risk scores (PRS) may serve as a viable tool to stratify patients based on their risk of invasive melanoma, according to a study published in JAMA Dermatology.

“It is unknown whether germline genetic factors influence in situ melanoma risk differently than invasive melanoma risk,” the researchers noted.

In 3 genome-wide association meta-analyses, researchers analyzed 6 genome-wide significant loci associated with in situ melanoma and 18 loci associated with invasive melanoma using 4 population-based genetic cohorts: the UK Biobank, the FinnGen cohort, the QSkin Sun and Health Study, and the Queensland Study of Melanoma: Environmental and Genetic Associations (Q-MEGA). Data were collected from 1987 to 2022, and they were analyzed from September 2022 to June 2023.
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