Age-related skin changes may contribute to melanoma metastases among older adults

Source: Healio, May 2024

Age-related changes to the skin’s elasticity may drive higher rates of metastatic skin cancer among older individuals, according to study results.

Increased stiffness in aging skin leads to elevated production of a protein called ICAM1.

Increases in ICAM1 concentration trigger the growth of blood vessels in a tumor, facilitating its growth. ICAM1 also causes blood vessels to become “leaky,” which induces tumor cells to escape and circulate throughout the body more easily.
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