Experts Give an Overview of the Latest Melanoma Therapies

Source: CureToday, February 2024

Dr. Inderjit Mehmi and Dr. Omid Hamid from the Angeles Clinic, explain how therapies like targeted therapies, immunotherapy and T-cell therapies are improving outcomes for patients with advanced melanoma.

Melanoma, a type of skin cancer, has been historically challenging tumor to treat in the advanced setting due to an aggressive nature and resistance to conventional treatments. Current discussions in our clinics with patients who are newly diagnosed with melanoma are filled with hope and promise. These discussions include topics like clinical trials, FDA-approved therapies ranging from target therapies to various modalities of immunotherapies to harness our body’s own abilities to control advance melanoma. Clinical trials that have led to FDA approvals of targeted agents, immunotherapy with check point inhibitors (CPI), with future approval expected for adoptive T-cell therapy, and immTACs (immune mobilizing T-cell receptor against cancer), have improved the prognosis of many with melanoma.

Melanoma, the deadliest type of skin cancer, arises from the uncontrolled growth of melanocytes, the cells responsible for producing melanin pigment in our skin. Though this disease is uncommon (with lifetime risk of 2.6% for Caucasian people, which is 20 times higher than Black people), it leads to significant life loss.
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