Study Identifies a Causal Relationship Between Psoriasis and Cutaneous Melanoma

Source: AJMC, September 2023

Psoriasis increases the risk of cutaneous melanoma, according to the findings of a new study.

Researchers of a bidirectional study found that genetically predicted psoriasis was a significant risk factor for cutaneous melanoma (CM), suggesting a causal relationship between psoriasis and CM.

“As a variant of the MR [Mendelian randomization] approach, bidirectional MR can be applied to ascertain the causal direction between 2 associated phenotypes,” wrote the researchers of the study. “In this study, we performed a bidirectional two-sample MR analysis using summary statistics of large GWASs [genome-wide association studies] from the FinnGen Consortium to assess the causal association between psoriasis and CM.”
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