CLL Treatment Affects ICI Efficacy in Patients With Melanoma and CLL
Source: Cancer Therapy Advisor, July 2023
Treating advanced melanoma with immune checkpoint inhibitors (ICIs) can be safe and effective in patients with concomitant chronic lymphocytic leukemia (CLL), according to a study published in Annals of Oncology.
The study did show, however, that patients who received prior or concurrent treatment for CLL had worse outcomes of ICI treatment than patients who were under observation for CLL.
In this retrospective analysis, researchers examined electronic health record data from 58 patients who had both CLL and advanced melanoma and were treated with an ICI during 1997-2020. The patients were from the United States (n=39) and Australia (n=19).