Comparing Therapy Options for Melanoma In-Transit Metastases
Source: Moffitt Cancer Center, June 2023
Melanoma is a type of skin cancer that forms in skin cells called melanocytes, which are responsible for producing the pigment that gives skin its color.
Melanoma in-transit metastases occur when melanoma skin cancer spreads through the dermal/skin lymphatic channels. There are many treatment options for this type of disease metastasis, including surgery, intratumoral injections, isolated-limb infusion or perfusion and immune checkpoint inhibitors (immunotherapy).
Intratumoral injection involves directly injecting the tumor site, and isolated-limb infusion involves isolating the vasculature of the limb and perfusing it with super high doses of cytotoxic chemotherapy. Immunotherapy involves stimulating the immune system throughout the body.