Every Patient With Metastatic Melanoma “Deserves a Shot at Nivolumab/Ipilimumab,” Weber Says
Source: Onc Live, November 2022
The combination of nivolumab (Opdivo) and ipilimumab (Yervoy) have shown overall survival (OS) benefit in patients with metastatic melanoma, according to long-term follow-up data, and other studies’ results highlight the efficacy and toxicity benefits of different sequences of the combination, Jeffrey S. Weber, MD, PhD, said during a presentation at the 40th Annual CFS®.
The phase 3 CheckMate 067 trial (NCT01844505), which randomly assigned patients with previously untreated, unresectable or metastatic melanoma 1:1:1 to receive the combination of nivolumab/ipilimumab, nivolumab alone, or ipilimumab alone, now has available data from 6.5 years of follow-up. “There are not a lot of studies out there in melanoma—in fact, I would say there are none—that have this kind of follow-up,” Weber noted.
The combination elicited a median OS of 72.1 months (95% CI, 38.2-not reached [NR]), compared with 36.9 months (95% CI, 28.2-58.7) for nivolumab alone (HR, 0.84; 95% CI, 0.67-1.04) and 19.9 months (95% CI, 16.8-24.6) for ipilimumab alone (HR, 0.52; 95% CI, 0.43-0.64). The 78-month OS rates were 49% for nivolumab/ipilimumab, 42% for nivolumab alone, and 23% for ipilimumab alone.