The predictive and prognostic significance of cell?free DNA concentration in melanoma

Source: MDLinx, February 2021

In this study with a discovery cohort (n = 20) and expansion cohort (n = 166) comprising metastatic melanoma cases and healthy donors (n = 116), researchers examined the link between circulating cell-free DNA (cfDNA) and potential confounders and assessed the monitoring value of total cfDNA level during treatment, and also evaluated its predictive as well as prognostic worth particularly in a wild-type melanoma patient population, to ultimately exploit cfDNA as a melanoma biomarker to its full extent.

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