Partial Chromosome 3 Deletion Tied to Poorer Survival in Uveal Melanomas

Source: Oncology Learning Network, February 2020

Findings from a cohort study showed that patients with uveal melanomas carrying a partial deletion of chromosome 3 encompassing the BAP1 locus have a poor prognosis compared with patients whose uveal melanomas lack such deletion (JAMA Ophthalmol. 2020 Jan 2. Epub ahead of print).

“Studies on uveal melanomas…have demonstrated the prognostic value of 8q gain and monosomy 3, but the prognosis of UMs [uveal melanomas] with partial deletion of chromosome 3 remains to be defined,” said Manuel Rodrigues, MD, PhD, Unit 830 (Cancer, Heterogeneity, Instability and Plasticity) INSERM, Institut Curie, PSL Research University, Paris, France, and colleagues.

Thus, they conducted a retrospective study of 1088 consecutive comparative genomic hybridization arrays performed from May 1, 2006, to July 31, 2015, to evaluate the link between partial chromosome 3 deletion in UMs and metastasis-free survival (MFS). Among the genomic hybridization arrays, 43 (4.0%) uveal melanomas in 43 patients (median age, 58 years) were found to carry partial deletions of chromosome 3.