Triplet Therapy With Novel PD-1 Inhibitor Holds Promise in Melanoma

Source: OnClive, December 2018

The addition of a novel PD-1 inhibitor to a combination of BRAF inhibitor dabrafenib (Tafinlar) and MEK inhibitor trametinib (Mekinist) is being tested to determine whether the triplet is safe and effective for patients with metastatic or unresectable melanoma. Although the combination of BRAF and MEK inhibitors is already a preferred treatment option for patients with BRAF V600 mutation–positive melanoma, investigators are hopeful that adding the PD-1 inhibitor spartalizumab (PDR001) will improve responses to therapy.1

Checkpoint inhibitors and other targeted therapies have improved outcomes for patients with advanced melanoma, but patients still have progression and die from the disease.

Spartalizumab is an investigational humanized monoclonal antibody that binds to PD-1 expressed on activated T cells and blocks the interactions with its ligands, PD-L1 and PD-L2. This inhibits PD-1 signaling, activates T cells, and induces an immune response to tumor cells,2 causing a reduction of tumor growth.3

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