Study reveals significant role of ADAMTS1 protein in uveal melanoma

Source: News Medical Life Sciences, January 2021

Scientists from the University of Granada and GENYO (Pfizer-University of Granada-Andalusian Government Centre for Genomics and Oncological Research), in a study led by Juan Carlos Rodríguez-Manzaneque, have demonstrated the significant role of a protein called ADAMTS1 in uveal melanoma, one of the rarest and most aggressive cancers that exist, which develops in the eye.

tumors are composed not only of a mass of cells that grow uncontrollably but also of the environment they create during their growth—together creating what is known as the ‘tumor microenvironment’.

Within this environment, there are proteins that remodel it, known as extracellular proteases, which are capable of inhibiting or contributing to tumor growth and metastasis.