Review: Baseline Gut Microbiota May Predict Immunotherapy Responses

Source: AJMC, July 2021

Dietary interventions with locally available fruits, vegetables, and whole grains might be an affordable and safe approach to enhancing the diversity of gut microbiota before immunotherapy, which may potentially improve patients’ treatment responses, according to recently published review findings.

Although alterations in the gut microbiota have previously been associated with several functional gastrointestinal disorders, this community of microorganisms has also been linked with genitourinary malignancies, including bladder, kidney, and prostate cancers, authors explained.

In addition, “recent intriguing evidence from several human clinical trials has suggested that the composition and diversity of the gut microbiota at baseline influences response to cancer immunotherapy.”

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