Possibility of vaccine to prevent skin cancer

Source: Science Daily, January 2022

Research by the Oregon State University College of Pharmacy suggests that a vaccine stimulating production of a protein critical to the skin’s antioxidant network could help people bolster their defenses against skin cancer.

Ultraviolet radiation from the sun leads to oxidative stress, which increases the risk of skin cancers such as melanoma, explains Arup Indra, professor of pharmaceutical sciences at OSU and the study’s leader.

A messenger RNA vaccine, like the Moderna and Pfizer vaccines for COVID-19, that promoted production of the protein, TR1, in skin cells could mitigate the risk of UV-induced cancers and other skin problems, he said.

Findings of the research, in which Arup and collaborators used a mouse model to probe TR1’s role in skin cells’ health and stability, were published in the Journal of Investigative Dermatology.

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