Melbourne Melanoma Project committed to improving the diagnosis and early detection of melanoma.

Fecal microbiota transplants help patients with advanced melanoma respond to immunotherapy

For patients with cancers that do not respond to immunotherapy drugs, adjusting the composition of microorganisms in the intestines — known as the gut microbiome — through the use of stool, or fecal, transplants may help some of these individuals respond to the immunotherapy drugs, a new study suggests.

Fecal Transplants May Quash Anti-PD-1 Resistance in Melanoma

A single fecal microbiota transplant (FMT) appeared to reprogram the gut microbiomes of advanced melanoma patients to overcome their primary resistance to anti-programmed cell death protein 1 (PD-1) immunotherapy, a small single-arm phase II trial found.

Clinical features of subungual melanoma according to the extent of Hutchinson’s nail sign: A retrospective single-centre study

Researchers sought to determine clinicopathological characteristics of subungual melanoma (SUM) according to the extent of Hutchinson’s nail sign (HS).

The predictive and prognostic significance of cell?free DNA concentration in melanoma

In this study with a discovery cohort (n = 20) and expansion cohort (n = 166) comprising metastatic melanoma cases and healthy donors (n = 116), researchers examined the link between circulating cell?free DNA (cfDNA) and potential confounders and assessed the monitoring value of total cfDNA level during treatment…