In Retrospective Research, the Prognostic Significance of Ulceration Varies Between Breslow Thicknesses and Clinical Stages in Acral Melanoma

Source: Physician’s Weekly, March 2022

Ulceration was a negative prognostic feature that was used to subcategorize cutaneous melanoma patients, along with tumor thickness. However, the impact of ulceration on the prognosis of acral melanoma (AM) was debatable. For a study, the researchers sought to examine the impact of ulceration on prognosis in AM and the variation in Breslow thicknesses and clinical stages. Patients diagnosed with AM between January 2000 and December 2017 were researched in a multi-center retrospective outline. The multivariate Cox proportional hazards model and log-rank test analyzed differences in melanoma-specific survival (MSS) between patients with and without ulceration. Ulceration was determined in 62.6% of the 1,053 individuals who took part in the research.