Germline Loss-of-Function Variants in ATM Gene May Contribute to Melanoma Predisposition

Source: Precision Oncology News, July 2021

NEW YORK —The ATM gene may contribute to melanoma predisposition as loss-of-function variants in it confer a moderate risk of disease, according to a new study.

Germline variants in ATM have been implicated in the risk of numerous cancers and while SNPs in ATM have been tied to melanoma risk, the effect of ATM on melanoma predisposition has been unclear. ATM encodes a protein active in the DNA damage response and is activated by DNA double-strand breaks, including damage caused by UV radiation.

READ THE ORIGINAL FULL ARTICLE
Menu