Genetic Patterns, Targeted Therapy Resistance Link in Melanoma Explored in New Study
Source: AJMC, July 2022
The analysis could help investigators better understand why a subset of patients with advanced melanoma develops resistance or does not respond to targeted therapy.
A new analysis has revealed a set of genetic patterns that appear to correlate with melanoma resistance to targeted therapy. The study, published in Journal of Investigative Dermatology, could help investigators understand why some patients with melanoma do not respond to treatment and it could lead to better personalized therapies for such patients.
Small-molecule therapies targeting BRAF and MEK kinases have become an important treatment option for patients with advanced metastatic melanoma, but a significant subset of patients do not respond to these therapies and some patients develop resistance leading to relapse.