Melanoma Research Victoria

Source: OncLive, February 2019 Transcript: Axel Hauschild, MD: Let’s make a cut here and use the last minute of this section to discuss intralesional approaches. There is so much clinical trial data out there. It’s confusing for those who are not experts in this field. T-VEC, Merrick, has an established role. It’s approved as single-agent therapy. […]

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Source: OncLive, February 2019 Transcript: Axel Hauschild, MD: When we discuss stage IV melanoma now, I think it’s good to provide a quick overview on ASCO [American Society of Clinical Oncology] 2018. Most of the trials that have been released as an update at ASCO with long-term survival data were done on PD-1 [programmed cell death […]

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Source: OncLive, February 2019 Evidence continues to build that tucatinib, a novel small molecule HER2 inhibitor, is safe and effective for patients with advanced HER2-positive breast cancer in combination with standard therapies, including for those who develop brain metastases from their primary disease. There are currently no systemic therapies that the FDA has specifically approved […]

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Source: OncLive, February 2019 Transcript: Michael A. Davies, MD, PhD: I think that the results that we’ve seen with ipilimumab and nivolumab in patients with brain metastases are remarkable. In both the CheckMate204 study published in the New England Journal of Medicine and the ABC study published in The Lancet Oncology, ipilimumab and nivolumab had intracranial response rates between 45% […]

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