Of Interest – Melanoma Research Victoria https://melanomaresearchvic.com.au Wed, 20 Jan 2021 06:59:05 +0000 en-US hourly 1 https://melanomaresearchvic.com.au/wp-content/uploads/2017/12/cropped-favicon-32x32.png Of Interest – Melanoma Research Victoria https://melanomaresearchvic.com.au 32 32 Texas A&M Research Explores How Melanoma Grows And Spreads https://melanomaresearchvic.com.au/texas-am-research-explores-how-melanoma-grows-and-spreads Fri, 22 Jan 2021 06:55:31 +0000 https://melanomaresearchvic.com.au/?p=16255 The first step in treating cancer is understanding how it starts, grows and spreads throughout the body.

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Source: TEXAS A&M TODAY, January 2021

The first step in treating cancer is understanding how it starts, grows and spreads throughout the body.

A relatively new cancer research approach is the study of metabolites, the products of different steps in cancer cell metabolism, and how those substances interact.

To date, research like this has focused mostly on cancerous tissues; however, normal tissues that surround tumors, known as the extratumoral microenvironment (EM), may have conditions favorable for tumor formation and should also be studied.

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Ultraviolet radiation causes rare type of eye cancer https://melanomaresearchvic.com.au/ultraviolet-radiation-causes-rare-type-of-eye-cancer Fri, 22 Jan 2021 06:50:50 +0000 https://melanomaresearchvic.com.au/?p=16253 Ultraviolet radiation can cause a rare type of eye cancer, conjunctival melanoma, according to University of Manchester research funded by Cancer Research UK and others* and published** in Nature Communications today (Monday).

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Source: The University of Manchester, January 2021

Ultraviolet radiation can cause a rare type of eye cancer, conjunctival melanoma, according to University of Manchester research funded by Cancer Research UK and others* and published** in Nature Communications today (Monday).

UV radiation is known to be the key environmental cause of melanoma of the skin, but its role in the development of rarer forms of melanoma in the eye was not known.

This new study has revealed strikingly similar genetic changes in conjunctival melanoma to that of cutaneous (skin) melanoma caused by ultraviolet (UV) radiation.

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Advanced humanized mouse model helps better understand immunotherapy resistance in melanoma https://melanomaresearchvic.com.au/advanced-humanized-mouse-model-helps-better-understand-immunotherapy-resistance-in-melanoma Fri, 22 Jan 2021 06:47:56 +0000 https://melanomaresearchvic.com.au/?p=16251 Scientists at The Wistar Institute have created an advanced humanized immune system mouse model that allows them to examine resistance to immune checkpoint blockade therapies in melanoma.

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Source: News Medical Life Sciences, January 2021

Scientists at The Wistar Institute have created an advanced humanized immune system mouse model that allows them to examine resistance to immune checkpoint blockade therapies in melanoma.

It has revealed a central role for mast cells. These findings were published today in the journal Nature Communications.

Checkpoint inhibitors revolutionized therapeutic options for advanced melanoma.

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New humanized mouse model provides insight into immunotherapy resistance https://melanomaresearchvic.com.au/new-humanized-mouse-model-provides-insight-into-immunotherapy-resistance Thu, 21 Jan 2021 06:37:07 +0000 https://melanomaresearchvic.com.au/?p=16247 Scientists at The Wistar Institute have created an advanced humanized immune system mouse model that allows them to examine resistance to immune checkpoint blockade therapies in melanoma.

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Source: EurekAlert!, January 2021

Scientists at The Wistar Institute have created an advanced humanized immune system mouse model that allows them to examine resistance to immune checkpoint blockade therapies in melanoma.

It has revealed a central role for mast cells.

These findings were published today in the journal Nature Communications.

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Regression may predict good prognosis in stage 1 and 2 cutaneous melanomas https://melanomaresearchvic.com.au/regression-may-predict-good-prognosis-in-stage-1-and-2-cutaneous-melanomas Thu, 21 Jan 2021 06:31:34 +0000 https://melanomaresearchvic.com.au/?p=16245 Disease regression was associated with improved recurrence-free survival and overall survival among certain patients with stage 1 and 2 cutaneous melanomas, according to a study.

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Source: Healio, January 2021

Disease regression was associated with improved recurrence-free survival and overall survival among certain patients with stage 1 and 2 cutaneous melanomas, according to a study.

“Although regression is commonly observed in cutaneous melanoma, it is uncertain whether it is associated with patient prognosis,” Mary-Ann El Sharouni, MD, of the Melanoma Institute Australia at The University of Sydney and the department of dermatology at University Medical Center Utrecht at Utrecht University, the Netherlands, and colleagues wrote.

In the cohort study involving 17,271 Dutch patients and 4,980 Australian patients with stage 1 and 2 primary cutaneous melanomas, the researchers aimed to determine whether histologically confirmed regression was associated with better or worse survival.

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Study reveals significant role of ADAMTS1 protein in uveal melanoma https://melanomaresearchvic.com.au/study-reveals-significant-role-of-adamts1-protein-in-uveal-melanoma Tue, 19 Jan 2021 04:58:37 +0000 https://melanomaresearchvic.com.au/?p=16229 Scientists from the University of Granada and GENYO (Pfizer-University of Granada-Andalusian Government Centre for Genomics and Oncological Research), in a study led by Juan Carlos Rodríguez-Manzaneque, have demonstrated the significant role of a protein called ADAMTS1 in uveal melanoma, one of the rarest and most aggressive cancers that exist, which develops in the eye.

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Source: News Medical Life Sciences, January 2021

Scientists from the University of Granada and GENYO (Pfizer-University of Granada-Andalusian Government Centre for Genomics and Oncological Research), in a study led by Juan Carlos Rodríguez-Manzaneque, have demonstrated the significant role of a protein called ADAMTS1 in uveal melanoma, one of the rarest and most aggressive cancers that exist, which develops in the eye.

tumors are composed not only of a mass of cells that grow uncontrollably but also of the environment they create during their growth—together creating what is known as the ‘tumor microenvironment’.

Within this environment, there are proteins that remodel it, known as extracellular proteases, which are capable of inhibiting or contributing to tumor growth and metastasis.

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The Yin and Yang of BRAF, MEK and CDK4-6 targeted therapy https://melanomaresearchvic.com.au/the-yin-and-yang-of-braf-mek-and-cdk4-6-targeted-therapy Mon, 18 Jan 2021 04:49:44 +0000 https://melanomaresearchvic.com.au/?p=16222 A new paper from the McArthur & Sheppard Laboratory, by Emily Lelliott et. al.

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A new paper from the McArthur & Sheppard Laboratory, by Emily Lelliott et. al.

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Improvements in treatments for NSCLC, blood cancers, and melanoma continue to accelerate annual drop in overall cancer mortality rates https://melanomaresearchvic.com.au/improvements-in-treatments-for-nsclc-blood-cancers-and-melanoma-continue-to-accelerate-annual-drop-in-overall-cancer-mortality-rates Mon, 18 Jan 2021 04:24:32 +0000 https://melanomaresearchvic.com.au/?p=16215 Overall cancer mortality rates in the United States continued to drop precipitously, falling by 2.4% from 2017-2018, according to the American Cancer Society’s latest Cancer Statistics report.

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Source: THE CANCER LETTER, January 2021

Overall cancer mortality rates in the United States continued to drop precipitously, falling by 2.4% from 2017-2018, according to the American Cancer Society’s latest Cancer Statistics report.

The Jan. 12 report notes that this drop, 2.4%, is the largest ever, greater than the previous year’s impressive 2.2% decline for 2016-2017—the largest one-year drop to date at the time (The Cancer Letter, Feb. 7, 2020).

New treatments for NSCLC are a primary contributor to the accelerating declines in lung cancer mortality, the main driver for the multi-decade drops in overall cancer mortality, the report said.

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Eruptive Cherry Angiomas and Skin Melanoma: Further Insights into an Intriguing Association. https://melanomaresearchvic.com.au/eruptive-cherry-angiomas-and-skin-melanoma-further-insights-into-an-intriguing-association Wed, 13 Jan 2021 12:04:25 +0000 https://melanomaresearchvic.com.au/?p=16192 Some risk factors for malignant melanoma (MM) are recognized.

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Source: Physician’s Weekly, December 2020

Some risk factors for malignant melanoma (MM) are recognized.
To compare the strength of association between MM and eruptive cherry angiomas (CAs) with that of other well-known associations.
This cross-sectional study included all subjects referred to the Outpatient Dermatology-Oncology and Dermoscopy Units of the Universities of Ferrara and Bologna, Italy, over a 5-month period and submitted to total body skin examination.

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Huntsman Cancer Institute researchers identify promising drug combination for melanoma https://melanomaresearchvic.com.au/huntsman-cancer-institute-researchers-identify-promising-drug-combination-for-melanoma Wed, 13 Jan 2021 11:54:48 +0000 https://melanomaresearchvic.com.au/?p=16188 Researchers at Huntsman Cancer Institute (HCI) at the University of Utah (U of U) have identified a potential drug combination to treat uveal melanoma, a type of eye cancer.

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Source: EurekAlert!, December 2020

Researchers at Huntsman Cancer Institute (HCI) at the University of Utah (U of U) have identified a potential drug combination to treat uveal melanoma, a type of eye cancer.

Lead author Amanda Truong, trainee in the McMahon Lab at HCI and student at the U of U, explains uveal melanoma patients frequently have changes in genes called GNAQ and GNA11, which are key targets for these drugs.

This study was published in the journal Clinical Cancer Research.

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