Archive | Scientific Publications

Pivotal factors associated with the immunosuppressive tumor microenvironment and melanoma metastasis

Researchers sought to determine the potential mechanisms underlying melanoma metastasis.

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Posted in Melanoma News, Publications, Scientific Publications

Monosomy 3 Is Linked to Resistance to MEK Inhibitors in Uveal Melanoma

The use of MEK inhibitors in the therapy of uveal melanoma (UM) has been investigated widely but has failed to show benefits in clinical trials due to fast acquisition of resistance.

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Posted in Melanoma News, Publications, Scientific Publications

AP-2alpha-mediated activation of E2F and EZH2 drives melanoma metastasis

To clarify the role of the AP-2alpha transcription factor, which is encoded by TFAP2A, in melanoma metastasis, researchers undertook this study.

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Posted in Melanoma News, Publications, Scientific Publications

STING agonist loaded lipid nanoparticles overcome anti-PD-1 resistance in melanoma lung metastasis via NK cell activation

BACKGROUND: Resistance to an immune checkpoint inhibitor (ICI) is a major obstacle in cancer immunotherapy.

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Posted in Melanoma News, Publications, Scientific Publications