Advanced humanized mouse model helps better understand immunotherapy resistance in melanoma

Source: News Medical Life Sciences, January 2021

Scientists at The Wistar Institute have created an advanced humanized immune system mouse model that allows them to examine resistance to immune checkpoint blockade therapies in melanoma.

It has revealed a central role for mast cells. These findings were published today in the journal Nature Communications.

Checkpoint inhibitors revolutionized therapeutic options for advanced melanoma.

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