Addition of TIL Therapy to Pembrolizumab Shows Efficacy in Advanced Melanoma, HNSCC, and Cervical Cancer

Source: OncLive, December 2021

The combination of tumor-infiltrating lymphocyte cell therapy with lifileucel or LN-145 and pembrolizumab demonstrated encouraging efficacy and safety in patients with advanced melanoma, head and neck squamous cell carcinoma, and cervical cancer who were naïve to immune checkpoint inhibitors.

The combination of tumor-infiltrating lymphocyte (TIL) cell therapy with lifileucel (LN-144) or LN-145 and pembrolizumab (Keytruda) demonstrated encouraging efficacy and safety in patients with advanced melanoma, head and neck squamous cell carcinoma (HNSCC), and cervical cancer who were naïve to immune checkpoint inhibitors (ICIs), according to data from the phase 2 IOV-COM-202 (NCT03645928) and C-145-04 (NCT03108495) trials.1

The findings, which were presented during the 2021 SITC Annual Meeting, showed that in 14 patients with cervical cancer who comprised cohort 3 of the C-145-04 trial, the overall response rate (ORR) with LN-145 plus pembrolizumab was 57.1% (n = 8; 95% CI, 28.9%-82.3%); this included 1 complete response (CR), 6 partial responses (PRs), 1 unconfirmed PR, and 5 best responses of stable disease (SD). At a median follow-up of 7.6 months, 71.4% (n = 5/7) of patients experienced ongoing confirmed responses.

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